dBET23( dBET-23 | dBET 23 | dBET23 )

Catalog No. M13067 CAS No. 1957234-83-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

dBET23
Note

Research use only, not for human use.
Brief Description

dBET23 is a BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays.
Description

dBET23 is a BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays.
In Vitro

dBET23 occupies the canonical binding sites on CRBN and BRD4BD1 for thalidomide and JQ1, respectively.
In Vivo

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Synonyms

dBET-23 | dBET 23 | dBET23
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

1957234-83-1
Formula Weight

885.39
Molecular Formula

C43H45ClN8O9S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 110 mg/mL (124.24 mM)
SMILES

O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1
Chemical Name

methyl 2-((6S)-4-(4-chlorophenyl)-2-((8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

1. Nowak RP, et al. Nat Chem Biol. 2018 Jun 11. doi: 10.1038/s41589-018-0055-y.

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