SNIPER(AR)-51( SNIPER AR-51 )

Catalog No. M13362 CAS No. 2113688-43-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SNIPER(AR)-51
Note

Research use only, not for human use.
Brief Description

SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker; induces proteasomal degradation of AR and shows effective protein knockdown activity.
Description

SNIPER(AR)-51 is a specific and nongenetic, protein degradation inducer of androgen receptor, consistiong of AR ligand and IAP ligand and linker; induces proteasomal degradation of AR and shows effective protein knockdown activity; inhibits AR-mediated gene expression and proliferation of androgen-dependent prostate cancer cells, and efficiently induces caspase activation and apoptosis in prostate cancer cells.
In Vitro

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In Vivo

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Synonyms

SNIPER AR-51
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

Cancer
Indication

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CAS Number

2113688-43-8
Formula Weight

984.226
Molecular Formula

C55H65N7O8S
Purity

>98% (HPLC)
Solubility

——
SMILES

C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=CC(OCCOCCOCCOCCOC5=CC=C(CN6C(C)=C(C#N)C(C7=CC=C(C#N)C=C7)=C6C)C=C5)=C4)=O)=CS3)CCC2)=O)=O
Chemical Name

(S)-N-((S)-2-((S)-2-(4-(3-(2-(2-(2-(2-(4-((3-cyano-4-(4-cyanophenyl)-2,5-dimethyl-1H-pyrrol-1-yl)methyl)phenoxy)ethoxy)ethoxy)ethoxy)ethoxy)benzoyl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide

1. Shibata N, et al. J Med Chem. 2017 Jun 23. doi: 10.1021/acs.jmedchem.7b00168.

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