KH 176( KH176 )

Catalog No. M13449 CAS No. 2162149-24-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

KH 176
Note

Research use only, not for human use.
Brief Description

KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator.
Description

KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator, shows potential treatment for mitochondrial disorders; retains brain microstructural coherence in the external capsule in Ndufs4 -/- mice and normalizes the increased lipid peroxidation in this area and the cerebral cortex, significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice.Other Indication Phase 2 Clinical.
In Vitro

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In Vivo

Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4?/? mice. Animal Model:Ndufs4?/? mice (Leigh Disease model).Dosage:10?mg/kg.Administration:IP, daily (PD14-PD45, 32 days).Result:Significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells.Resulted in statistically significantly higher FA values in the external capsule and a similar trend was found in the cerebral peduncle.
Synonyms

KH176
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Other Indications
Indication

Other Disease

CAS Number

2162149-24-6
Formula Weight

368.902
Molecular Formula

C19H29ClN2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 170 mg/mL (460.83 mM)
SMILES

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Chemical Name

(S)-6-hydroxy-2,5,7,8-tetramethyl-N-((R)-piperidin-3-yl)chroman-2-carboxamide hydrochloride

1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733. 2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163.

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