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1400W dihydrochloride

CAS No. 214358-33-5

1400W dihydrochloride( —— )

Catalog No. M13428 CAS No. 214358-33-5

1400 W is a highly potent and selective inhibitor of inducible NOS2 (iNOS).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 46 In Stock
5MG 41 In Stock
10MG 65 In Stock
25MG 121 In Stock
50MG 215 In Stock
100MG 365 In Stock
200MG 475 In Stock
500MG 771 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    1400W dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    1400 W is a highly potent and selective inhibitor of inducible NOS2 (iNOS).
  • Description
    1400 W is a highly potent and selective inhibitor of inducible NOS2 (iNOS).
  • In Vitro
    1400W is a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W shows saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 μM. Inhibition is dependent on the cofactor NADPH. 1400W is at least 5000-fold selective for iNOS versus eNOS. In contrast, inhibition of human neuronal NOS and endothelial NOS (eNOS) is relatively weaker, rapidly reversible, and competitive with L-arginine, with Ki values of 2 μM and 50 μM, respectively. 1400W treatment inhibits iNOS expression without affecting nNOS or eNOS. 1400W also reduces NO, 3-NT and MDA production, and prevents neuronal cell apoptosis in cerebral cortex.
  • In Vivo
    1400W potently (ED50=0.3 mg/kg) reduces the delayed vascular injury in rats attributable to LPS-induced iNOS but fails to exacerbate acute vascular leakage when given concurrently with LPS. Administration of 1400W lowers NOx levels in all the experimental groups. In addition, lipid peroxidation, the percentage of apoptotic cells, and nitrated protein expression fall in the late post-hypoxia period (48 h and 5 days).
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    eNOS| iNOS| nNOS
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    214358-33-5
  • Formula Weight
    213.709
  • Molecular Formula
    C10H16ClN3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:0.25 mg/ml; DMF :0.25 mg/ml; Ethanol :0.25 mg/ml: Water :100 mM
  • SMILES
    CC(=NCC1=CC(=CC=C1)CN)N.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Thomsen LL1, Scott JM, Topley P, Knowles RG, Keerie AJ, Frend AJ.Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.Cancer Res. 1997 Aug 1;57(15):3300-4.
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