MALT1 paracaspase inhibitor 3( —— )

Catalog No. M13256 CAS No. 2088355-90-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

MALT1 paracaspase inhibitor 3
Note

Research use only, not for human use.
Brief Description

MALT1 paracaspase inhibitor 3 is a potent, specific, covalent inhibitor of MALT1 paracaspase with Ki of 10 nM.
Description

MALT1 paracaspase inhibitor 3 is a potent, specific, covalent inhibitor of MALT1 paracaspase with Ki of 10 nM, exhibits 10-and 100-fold improved potency in vitro and in vivo compared with Z-VRPR-fmk; binds covalently to the catalytic cysteine (C464) of MALT1, induces MALT1 oligomerization; exhibits potent activity in the Raji-GloSensor MALT1 protease inhibition (IC50=60 nM) and OCI-Ly3 growth inhibition assays (IC50=0.1 uM), selectively inhibits the growth of MALT1 dependent cell lines by decreasing cell proliferation and increasing apoptosis; downregulated IL10 protein expression in vitro and in vivo, also decreases STAT3 phosphorylation in ABC DLBCL cells; suppresses the growth of ABC DLBCL tumors in vivo.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Caspase
Recptor

Caspase
Research Area

——
Indication

——

CAS Number

2088355-90-0
Formula Weight

569.476
Molecular Formula

C24H34BrFN6O4
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)C(C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)CF)NC(=O)C2=CC=C(C=C2)Br
Chemical Name

(S)-1-((4-bromobenzoyl)-L-valyl)-N-((S)-1-fluoro-6-guanidino-2-oxohexan-3-yl)pyrrolidine-2-carboxamide

1. Fontán L, et al. J Clin Invest. 2018 Jul 19. pii: 99436.

Calculator

molnova catalog