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ZM 336372
CAS No. 208260-29-1
ZM 336372( ZM336372 | ZM-336372 )
Catalog No. M13244 CAS No. 208260-29-1
ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 50 | In Stock |
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| 2MG | 32 | In Stock |
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| 5MG | 50 | In Stock |
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| 10MG | 84 | In Stock |
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| 25MG | 158 | In Stock |
|
| 50MG | 281 | In Stock |
|
| 100MG | 492 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZM 336372
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NoteResearch use only, not for human use.
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Brief DescriptionZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM).
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DescriptionZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2; suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells, with marked induction of the cell cycle inhibitors p21 and p18; blocks cellular proliferation and suppresses NE vasoactive peptide production in pheochromocytoma cells.
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In Vitro——
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In Vivo——
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SynonymsZM336372 | ZM-336372
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PathwayMAPK/ERK Signaling
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TargetRaf
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RecptorC-Raf
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number208260-29-1
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Formula Weight389.4
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Molecular FormulaC23H23N3O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=C(C)C(NC(C2=CC=C(O)C=C2)=O)=C1)C3=CC=CC(N(C)C)=C3
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Chemical NameBenzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hall-Jackson CA, et al. Chem Biol. 1999 Aug;6(8):559-68.
2. Van Gompel JJ, et al. Mol Cancer Ther. 2005 Jun;4(6):910-7.
3. Kappes A, et al. J Surg Res. 2006 Jun 1;133(1):42-5.
4. Kunnimalaiyaan M, et al. Surgery. 2007 Dec;142(6):959-64; discussion 959-64.
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