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GW 5074
CAS No. 220904-83-6
GW 5074( GW-5074 | GW5074 )
Catalog No. M13521 CAS No. 220904-83-6
A potent, selective c-Raf inhibitor with IC50 of 9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 64 | In Stock |
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| 2MG | 34 | In Stock |
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| 5MG | 51 | In Stock |
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| 10MG | 79 | In Stock |
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| 25MG | 128 | In Stock |
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| 50MG | 159 | In Stock |
|
| 100MG | 193 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGW 5074
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective c-Raf inhibitor with IC50 of 9 nM.
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DescriptionA potent, selective c-Raf inhibitor with IC50 of 9 nM; shows >1000-fold selectivity for raf kinase versus CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms.
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In Vitro——
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In Vivo——
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SynonymsGW-5074 | GW5074
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PathwayMAPK/ERK Signaling
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TargetRaf
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RecptorC-Raf
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number220904-83-6
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Formula Weight520.942
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Molecular FormulaC15H8Br2INO2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1NC2=C(C=C(I)C=C2)/C1=C/C3=CC(Br)=C(O)C(Br)=C3
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Chemical Name2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lackey K, et al. Bioorg Med Chem Lett. 2000 Feb 7;10(3):223-6.
2. Yue X, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):57-9.
3. Jensen HA, et al. Cell Signal. 2015 Aug;27(8):1666-75.
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