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Semaxanib

CAS No. 194413-58-6

Semaxanib ( SU5416 )

Catalog No. M13045 CAS No. 194413-58-6

Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM.

Purity : >98% (HPLC)

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Biological Information

Product Name

Semaxanib
Note

Research use only, not for human use.
Brief Description

Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM.
Description

Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.
In Vitro

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In Vivo

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Synonyms

SU5416
Pathway

Angiogenesis
Target

VEGFR
Recptor

VEGFR2/Flk1
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

194413-58-6
Formula Weight

238.28
Molecular Formula

C15H14N2O
Purity

>98% (HPLC)
Solubility

Ethanol: 2 mg/mL (8.39 mM); DMSO: 22 mg/mL (92.32 mM)
SMILES

CC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Fong TA, et al. Y Res, 1999, 59(1), 99-106.

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