Cart
sales@molnova.com
Sulfatinib (b)
CAS No. 1308672-74-3
Sulfatinib (b)( HMPL-012 | Surufatinib | HMPL012 )
Catalog No. M11232 CAS No. 1308672-74-3
Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 72 | In Stock |
|
| 5MG | 68 | In Stock |
|
| 10MG | 92 | In Stock |
|
| 25MG | 151 | In Stock |
|
| 50MG | 222 | In Stock |
|
| 100MG | 346 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSulfatinib (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionSulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively.
-
DescriptionSulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively; also potently inhibits TrkB and FLT-3 with IC50 of 41 and 67 nM, shows little to no activity against other 278 other kinases (IC50>150 nM); targets tumor angiogenesis and immune modulation, exhibits an acceptable safety profile and encouraging antitumor activity in clinical investigations.Brain Cancer Phase 3 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsHMPL-012 | Surufatinib | HMPL012
-
PathwayAngiogenesis
-
TargetVEGFR
-
RecptorVEGFR
-
Research AreaCancer
-
IndicationBrain Cancer
Chemical Information
-
CAS Number1308672-74-3
-
Formula Weight480.5825
-
Molecular FormulaC24H28N6O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 30 mg/mL
-
SMILESCC1=CC2=C(N1)C=CC(OC3=NC(NC4=CC(CS(NCCN(C)C)(=O)=O)=CC=C4)=NC=C3)=C2
-
Chemical NameBenzenemethanesulfonamide, N-[2-(dimethylamino)ethyl]-3-[[4-[(2-methyl-1H-indol-5-yl)oxy]-2-pyrimidinyl]amino]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Xu JM, et al. Oncotarget. 2017 Jun 27;8(26):42076-42086.
molnova catalog
related products
-
TIE-2/VEGFR-2 kinase...
TIE-2/VEGFR-2 kinase-IN-5 (TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor) is a potent agent with anti-angiogenic activity, commonly used in biomedical research focused on angiogenesis.
-
Tivozanib hydrochlor...
Tivozanib hydrochloride hydrate (AV-951 hydrochloride hydrate) is an orally active, selective, and potent vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor that inhibits VEGFR-1, VEGFR-2, and VEGFR-3.
-
Motesanib diphosphat...
A potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.
