PRI-724( PRI 724 | PRI724 )

Catalog No. M16152 CAS No. 847591-62-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PRI-724
Note

Research use only, not for human use.
Brief Description

PRI-724 (PRI724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.
Description

PRI-724 (PRI724) is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM, an isomer or enantiomer of ICG-001; binds specifically to the co-activator CBP, but not to p300; selectively induce apoptosis in colon carcinoma cells but not in normal colon cells, and exhibits antitumor activity in the mouse xenograft models of colon cancer.Blood Cancer Phase 2 Clinical.
In Vitro

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In Vivo

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Synonyms

PRI 724 | PRI724
Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Wnt/β-catenin
Research Area

Cancer
Indication

Blood cancer

CAS Number

847591-62-2
Formula Weight

548.63
Molecular Formula

C33H32N4O4
Purity

>98% (HPLC)
Solubility

DMSO: 54.9 mg/mL (100 mM)；Ethanol: 27.4 mg/mL (50 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

C1CN([C@H]2CN(C(=O)[C@@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
Chemical Name

(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

1. Sasaki T, et al. Transl Respir Med. 2014 Sep 11;2:8. 2. Zhang X, et al. Am J Cancer Res. 2015 Jul 15;5(8):2344-60.

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