Cart
sales@molnova.com
IACS-4619
CAS No. 1884209-98-6
IACS-4619( IACS4619 )
Catalog No. M12939 CAS No. 1884209-98-6
IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameIACS-4619
-
NoteResearch use only, not for human use.
-
Brief DescriptionIACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.
-
DescriptionIACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM; shows no off-target kinase activity in a panel of 97 kinases; exhibits excellent cell permeability and good metabolic stability in microsomes; an excellent tool for interrogation of the utility of MTH1 inhibition in the context of oncology.
-
In Vitro——
-
In Vivo——
-
SynonymsIACS4619
-
PathwayCell Cycle/DNA Damage
-
TargetDNA Repair Protein
-
RecptorDNA Repair Protein
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1884209-98-6
-
Formula Weight195.266
-
Molecular FormulaC10H17N3O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name5-methyl-4-(neopentyloxy)pyrimidin-2-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-7.
molnova catalog
related products
-
PFM39
PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM.
-
6-Hydroxy-DL-DOPA
6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
-
NSC 19630
NSC 19630 (MIRA-1) is a potent, selective Werner syndrome helicase (WRN helicase) with IC50 of 20 uM.
