6-Hydroxy-DL-DOPA

Research use only, not for human use.

6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.

6-Hydroxy-DL-DOPA is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM; inhibits RAD52 foci formation in murine hematopoietic cells deficient in BRCA1, and kills BRCA-deficient cancer cells; also inhibits human apurinic/apyrimidinic endonuclease APE1 and enhances the cytotoxic and genotoxic potency of the alkylating agent methylmethane sulfonate.

6-Hydroxy-DOPA (0~20 μM; U20S cells) selectively inhibits RAD52-mediated recombination. 6-Hydroxy-DOPA (0~10 μM; HEK293T cells) decreases the number of eGFP-RAD52 foci in a dose-dependent manner. 6-Hydroxy-DOPA (5~75 μM; HCC1937 cells) selectively reduces the viability of the BRCA1-deficient triple-negative breast cancer cell line HCC1937.

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6-Hydroxy-DL-DOPA

Cell Cycle/DNA Damage

DNA Repair Protein

DNA Repair Protein

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21373-30-8

213.189

C9H11NO5

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (234.53 mM)

NC(CC1=CC(O)=C(O)C=C1O)C(O)=O

Alanine, 3-(2,4,5-trihydroxyphenyl)- (7CI,8CI)

(-20℃)

With Ice Pack

≥ 2 years