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Home - Products - Cell Cycle/DNA Damage - DNA Repair Protein - PFM39

PFM39

CAS No. 1310744-67-2

PFM39( SML1839 )

Catalog No. M11247 CAS No. 1310744-67-2

PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PFM39
  • Note
    Research use only, not for human use.
  • Brief Description
    PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM.
  • Description
    PFM39 (SML1839) is a small molecule that specifically inhibits exonuclease activity of MRE11, binds in the active site similar to mirin, inhibits dsDNA end resection in A549 cells with IC50 of 50-75 uM, inhibits HR without significantly increasing NHEJ.
  • In Vitro
    PFM39 (100 μM) treatment impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR). PFM39 (50 μM) inhibits homologous recombination (HR) without significantly increasing NHEJ.
  • In Vivo
    ——
  • Synonyms
    SML1839
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA Repair Protein
  • Recptor
    DNA Repair Protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1310744-67-2
  • Formula Weight
    219.262
  • Molecular Formula
    C10H9N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (456.08 mM)
  • SMILES
    O=C1N=C(N)S/C1=C\C2=CC=C(N)C=C2
  • Chemical Name
    (5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18. 2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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