SLLN-15

Research use only, not for human use.

SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models.

SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation and ; induced a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux, associated with a selective inhibition of AKT-MTOR signaling; SLLN-15-induced autophagy in TNBC cells was also associated with decreased AURKA expression decreased AKT phosphorylation and subsequent blockage of the AKT-MTOR pathway; demonstrates anticancer and anti-metastatic activity in mice bearing TNBC.

——

——

Autophagy inducer SLLN-15

Autophagy

Autophagy

Autophagy

——

——

——

507.362

C19H23N7Se2

>98% (HPLC)

——

C12=NC(NC3=CC=C(N4CC[Se]CC4)C=C3)=NC(N[C@@H]5C[Se]CC5)=C1N=CN2

(S)-N2-(4-selenomorpholinophenyl)-N6-(tetrahydroselenophen-3-yl)-9H-purine-2,6-diamine

(-20℃)

With Ice Pack

≥ 2 years