AZD-0156( AZD0156 | AZD 0156 )

Catalog No. M12809 CAS No. 1821428-35-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

AZD-0156
Note

Research use only, not for human use.
Brief Description

AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM inhibitor; exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.Solid Tumors,Phase 1 Clinical
Description

AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM inhibitor; exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.Solid Tumors Phase 1 Clinical(In Vitro):AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
In Vitro

AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
In Vivo

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Synonyms

AZD0156 | AZD 0156
Pathway

Cell Cycle/DNA Damage
Target

ATM/ATR
Recptor

ATM
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1821428-35-6
Formula Weight

461.556
Molecular Formula

C26H31N5O3
Purity

>98% (HPLC)
Solubility

DMSO: 6.2 mg/mL (Need ultrasonic and warming)
SMILES

O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3
Chemical Name

2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-

1. Degorce SL, et al. J Med Chem. 2016 Jul 14;59(13):6281-92. 2. Morgado-Palacin I, et al. Sci Signal. 2016 Sep 13;9(445):ra91.

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