KU-60019 (b)( KU60019 | KU 60019 | KU-60019. )

Catalog No. M16634 CAS No. 925701-49-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

KU-60019 (b)
Note

Research use only, not for human use.
Brief Description

KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays.
Description

KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM in cell-free assays, 270- and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.
In Vitro

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In Vivo

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Synonyms

KU60019 | KU 60019 | KU-60019.
Pathway

Cell Cycle/DNA Damage
Target

ATM/ATR
Recptor

ATM
Research Area

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Indication

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CAS Number

925701-49-1
Formula Weight

547.67
Molecular Formula

C30H33N3O5S
Purity

>98% (HPLC)
Solubility

DMSO: 18 mg/mL warmed (32.86 mM)
SMILES

O=C(NC1=CC(CC2=C(C(C3=CC(C=C(N4CCOCC4)O3)=O)=CC=C2)S5)=C5C=C1)CN6C[C@H](C)O[C@H](C)C6
Chemical Name

2-((2S,6R)-2,6-dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide.

1.Golding SE, et al. Mol Y Ther, 2009, 8(10), 2894-2902.

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