PG-S3-001( —— )

Catalog No. M13182 CAS No. 2047372-50-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PG-S3-001
Note

Research use only, not for human use.
Brief Description

PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.
Description

PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.
In Vitro

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In Vivo

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Synonyms

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Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

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Indication

——

CAS Number

2047372-50-7
Formula Weight

652.677
Molecular Formula

C32H33F5N2O5S
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

4-{(4-Cyclohexyl-benzyl)-[3-methyl-2-(methyl-pentafluorobenzenesulfonyl-amino)-butyryl]-amino}-benzoic acid

1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.

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