VTP-43742( Vimirogant | VTP43742 )

Catalog No. M12754 CAS No. 1802706-04-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

VTP-43742
Note

Research use only, not for human use.
Brief Description

VTP-43742 (Vimirogant, VTP43742) is a highly potent, selective, oral RORγt inverse agonist for the treatment of autoimmune disorders.
Description

VTP-43742 (Vimirogant, VTP43742) is a highly potent, selective, oral RORγt inverse agonist for the treatment of autoimmune disorders, including multiple sclerosis and psoriasis.Psoriasis Phase 2 Clinical.
In Vitro

Vimirogant inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM).
In Vivo

In the MOG35-55/CFA immunized mouse EAE model, Vimirogant (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord.
Synonyms

Vimirogant | VTP43742
Pathway

Nuclear Receptor/Transcription Factor
Target

ROR
Recptor

ROR
Research Area

Inflammation/Immunology
Indication

Psoriasis

CAS Number

1802706-04-2
Formula Weight

552.657
Molecular Formula

C27H35F3N4O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CN=C([C@H](C(C)C)N(C[C@H]2CC[C@H](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4
Chemical Name

(S)-N-((5-(ethylsulfonyl)pyridin-2-yl)methyl)-7-isopropyl-6-(((1r,4S)-4-(trifluoromethyl)cyclohexyl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide

1.?Pandya VB, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00588.

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