AZD-0284( AZD0284 )

Catalog No. M13333 CAS No. 2101291-07-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZD-0284
Note

Research use only, not for human use.
Brief Description

AZD-0284 is a potent, selective, inverse agonist of the nuclear receptor RORγ for the potential treatment of Plaque psoriasis.
Description

AZD-0284 is a potent, selective, inverse agonist of the nuclear receptor RORγ for the potential treatment of Plaque psoriasis.Psoriasis Phase 1 Clinical.
In Vitro

AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells.AZD0284 reduces polarization of TH17 into pathogenic TH17/1 cells. AZD0284 decreases frequency of single IL-17+cell as well as double positive TH17/1 cells. AZD0284 reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22 and IL-23R.
In Vivo

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Synonyms

AZD0284
Pathway

Nuclear Receptor/Transcription Factor
Target

ROR
Recptor

ROR
Research Area

Inflammation/Immunology
Indication

Psoriasis

CAS Number

2101291-07-8
Formula Weight

524.434
Molecular Formula

C21H18F6N2O5S
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL 190.68 mM
SMILES

O=C([C@@H]1N(C(C)=O)CC2=C1C=CC(S(=O)(C)=O)=C2)NC3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C3
Chemical Name

(R)-2-acetyl-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-5-(methylsulfonyl)isoindoline-1-carboxamide