SR0987( SR-0987 | SR0987 | SR 0987 )

Catalog No. M19376 CAS No. 303126-97-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SR0987
Note

Research use only, not for human use.
Brief Description

SR0987 is a RORγt agonist,
Description

SR-0987 is a T cell-specific RORγ (RORγt) agonist. SR-0987 induces IL-17 expression and decreases PD-1 expression in T cells in vitro.
In Vitro

SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.
In Vivo

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Synonyms

SR-0987 | SR0987 | SR 0987
Pathway

Nuclear Receptor/Transcription Factor
Target

ROR
Recptor

RORγt
Research Area

——
Indication

——

CAS Number

303126-97-8
Formula Weight

397.7
Molecular Formula

C16H10ClF6NO2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 150 mg/mL 377.17 mM H2O : < 0.1 mg/mL
SMILES

O=C(Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c2ccccc2Cl
Chemical Name

2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide

1.Chang MR, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8.

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