AZD-7986( INS-1007 | AZD 7986 | INS 1007 )

Catalog No. M12750 CAS No. 1802148-05-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZD-7986
Note

Research use only, not for human use.
Brief Description

AZD-7986(INS-1007, AZD7986) is a highly potent, reversible, and selective DPP1 inhibitor with enzyme and cell pIC50 of 8.4.
Description

AZD-7986(INS-1007, AZD7986) is a highly potent, reversible, and selective DPP1 inhibitor with enzyme and cell pIC50 of 8.4; shows excellent selectivity over other cathepsins, including cathepsins S, L, B, K, D, E, Z, H, and G; inhibits activation of all three NSPs (NE, Pr3, and CatG) with pIC50 of 7 in human primary bone marrow-derived CD34+ neutrophil progenitor cells; exhibits suitable human PK properties and is a clinical candidate for COPD.COPD Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

INS-1007 | AZD 7986 | INS 1007
Pathway

Metabolic Enzyme/Protease
Target

DPP
Recptor

DPP
Research Area

Inflammation/Immunology
Indication

COPD

CAS Number

1802148-05-5
Formula Weight

420.469
Molecular Formula

C23H24N4O4
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL 237.83 mM; H2O : < 0.1 mg/mL
SMILES

N#C[C@H](CC1=CC=C(C2=CC=C(OC(N3C)=O)C3=C2)C=C1)NC([C@H]4OCCCNC4)=O
Chemical Name

(S)-N-((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide

1. Doyle K, et al. J Med Chem. 2016 Oct 27;59(20):9457-9472.

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