HEC72702( HEC-72702 | HEC 72702 )

Catalog No. M12703 CAS No. 1793063-59-8

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Product Name

HEC72702
Note

Research use only, not for human use.
Brief Description

HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM.
Description

HEC72702 is a novel potent, orally active inhibitor of HBV capsid assembly, inhibits HBV-DNA levels in HepG.2.2.15 cells with IC50 of 39 nM; displays no induction of the CYP1A2, CYP3A4, or CYP2B6 enzyme at 10 uM, demonstrates a good systemic exposure and high oral bioavailability and achieves a viral-load reduction greater than 2 log in a hydrodynamic-injected (HDI) HBV mouse model.
In Vitro

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In Vivo

Animal Model:6-7 weeks, 16-18 g, Female BALB/c mice(HDI mouse model)Dosage:50, 100 mg/kg Administration:P.o.; daily for 7 days Result:Demonstrated a dose-dependent reduction of HBV DNA in the plasma of infected mice.
Synonyms

HEC-72702 | HEC 72702
Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

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Indication

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CAS Number

1793063-59-8
Formula Weight

581.457
Molecular Formula

C24H26BrFN4O5S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(OCC)C1=C(NC(C2=NC=CS2)=N[C@H]1C3=C(Br)C=C(F)C=C3)CN4CCO[C@H](CCC(O)=O)C4
Chemical Name

3-((R)-4-(((R)-6-(2-Bromo-4- fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)- 3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic acid

1. Ren Q, et al. J Med Chem. 2018 Feb 8;61(3):1355-1374.

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