β-catenin-IN-37( —— )

Catalog No. M12685 CAS No. 1783856-40-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

β-catenin-IN-37
Note

Research use only, not for human use.
Brief Description

β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM.
Description

β-catenin-IN-37 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 17 uM; suppresses canonical Wnt signaling, downregulates the expression of Wnt target genes; inhibits the growth of Wnt-activated cancer cells with the IC50 values of 26 uM and 31 uM for SW480 and HCT116 cells, respectively.
In Vitro

β-catenin-IN-37 displays Ki values of 17 μM and 18 μM forβ-catenin/Tcf PPI in FP assay and in Alpha Screen assay, respectively.
In Vivo

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Synonyms

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Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Beta-catenin
Research Area

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Indication

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CAS Number

1783856-40-5
Formula Weight

307.277
Molecular Formula

C13H9N9O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (325.45 mM)
SMILES

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Chemical Name

5-(2-(2H-Tetrazol-5-yl)ethyl)-5H-[1,2,5]oxadiazolo[3',4':5,6]-pyrazino[2,3-b]indole

1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92.

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