CCT-031374( CCT031374 )

Catalog No. M14506 CAS No. 442535-46-8

CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

CCT-031374
Note

Research use only, not for human use.
Brief Description

CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM.
Description

CCT-031374 is a selective β-catenin signaling inhibitor with IC50 of 6.1 uM; prevents BIO-induced accumulation of β-catenin, does not alter β-catenin levels but blocks transcription at the β-catenin level; also shows activity against endogenous LEF-1 mRNA levels in human neurogenic embryoid bodies (hNEBs) in which Wnt signaling had been induced by BIO.
In Vitro

——
In Vivo

——
Synonyms

CCT031374
Pathway

Wnt/Notch/Hedgehog
Target

Beta-catenin
Recptor

Beta-catenin
Research Area

——
Indication

——

Chemical Information

CAS Number

442535-46-8
Formula Weight

353.425
Molecular Formula

C23H19N3O
Purity

>98% (HPLC)
Solubility

——
SMILES

C1CN2C3=CC=CC=C3N(C2=N1)CC(=O)C4=CC=C(C=C4)C5=CC=CC=C5.Br
Chemical Name

1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ewan K, et al. Cancer Res. 2010 Jul 15;70(14):5963-73. 2. Yang Y, et al. Neuroscience. 2013 Sep 17;248:383-91. 3. Liu B, et al. Int J Mol Med. 2015 Dec;36(6):1572-82.

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