Cart
sales@molnova.com
Flavokawain B
CAS No. 1775-97-9
Flavokawain B( Flavokawain B | Flavokawain-B | FlavokawainB )
Catalog No. M12673 CAS No. 1775-97-9
Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 155 | In Stock |
|
| 10MG | 250 | In Stock |
|
| 25MG | 425 | In Stock |
|
| 50MG | 601 | In Stock |
|
| 100MG | 826 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameFlavokawain B
-
NoteResearch use only, not for human use.
-
Brief DescriptionFlavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM).
-
DescriptionFlavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression; induces apoptosis in human myeloid leukemic cells by modifying NF-κB, possesses potential anti-inflammation and anti-cancer activities; also exhibits significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin in mice.
-
In Vitro——
-
In Vivo——
-
SynonymsFlavokawain B | Flavokawain-B | FlavokawainB
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1775-97-9
-
Formula Weight284.311
-
Molecular FormulaC17H16O4
-
Purity>98% (HPLC)
-
SolubilityChloroform: Soluble Dichloromethane: SolubleEthyl Acetate: SolubleAcetone: SolubleDMSO: 38 mg/mL (133.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESO=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=CC=C2
-
Chemical Name2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Tang Y, et al. Int J Cancer. 2010 Oct 15;127(8):1758-68.
2. Lee JJ, et al. Anticancer Res. 2018 May;38(5):2771-2778.
3. Mohamad AS, et al. Eur J Pharmacol. 2010 Nov 25;647(1-3):103-9.
4. Abu N, et al. Nat Prod Commun. 2015 Jul;10(7):1199-202.
molnova catalog
related products
-
Phenoxodiol
Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis.
-
Naphthazarin
Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation.
-
DT2216
DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extremely large (BCL-XL), proteolytic targeting chimera (PROTAC).
