Flavokawain B

CAS No. 1775-97-9

Flavokawain B( Flavokawain B | Flavokawain-B | FlavokawainB )

Catalog No. M12673 CAS No. 1775-97-9

Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 155 In Stock
10MG 250 In Stock
25MG 425 In Stock
50MG 601 In Stock
100MG 826 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Flavokawain B
  • Note
    Research use only, not for human use.
  • Brief Description
    Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM).
  • Description
    Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression; induces apoptosis in human myeloid leukemic cells by modifying NF-κB, possesses potential anti-inflammation and anti-cancer activities; also exhibits significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Flavokawain B | Flavokawain-B | FlavokawainB
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1775-97-9
  • Formula Weight
    284.311
  • Molecular Formula
    C17H16O4
  • Purity
    >98% (HPLC)
  • Solubility
    Chloroform: Soluble Dichloromethane: SolubleEthyl Acetate: SolubleAcetone: SolubleDMSO: 38 mg/mL (133.7 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=CC=C2
  • Chemical Name
    2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tang Y, et al. Int J Cancer. 2010 Oct 15;127(8):1758-68. 2. Lee JJ, et al. Anticancer Res. 2018 May;38(5):2771-2778. 3. Mohamad AS, et al. Eur J Pharmacol. 2010 Nov 25;647(1-3):103-9. 4. Abu N, et al. Nat Prod Commun. 2015 Jul;10(7):1199-202.
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