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Flavokawain B

CAS No. 1775-97-9

Flavokawain B( Flavokawain B | Flavokawain-B | FlavokawainB )

Catalog No. M12673 CAS No. 1775-97-9

Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Flavokawain B
  • Note
    Research use only, not for human use.
  • Brief Description
    Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM).
  • Description
    Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression; induces apoptosis in human myeloid leukemic cells by modifying NF-κB, possesses potential anti-inflammation and anti-cancer activities; also exhibits significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Flavokawain B | Flavokawain-B | FlavokawainB
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1775-97-9
  • Formula Weight
    284.311
  • Molecular Formula
    C17H16O4
  • Purity
    >98% (HPLC)
  • Solubility
    Chloroform: Soluble Dichloromethane: SolubleEthyl Acetate: SolubleAcetone: SolubleDMSO: 38 mg/mL (133.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=CC=C2
  • Chemical Name
    2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tang Y, et al. Int J Cancer. 2010 Oct 15;127(8):1758-68. 2. Lee JJ, et al. Anticancer Res. 2018 May;38(5):2771-2778. 3. Mohamad AS, et al. Eur J Pharmacol. 2010 Nov 25;647(1-3):103-9. 4. Abu N, et al. Nat Prod Commun. 2015 Jul;10(7):1199-202.
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