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GSK854

CAS No. 1316059-00-3

GSK854( —— )

Catalog No. M33986 CAS No. 1316059-00-3

GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury, and adverse remodeling in the ischemic heart.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	149	Get Quote
5MG	235	Get Quote
10MG	377	Get Quote
25MG	725	Get Quote
50MG	1086	Get Quote
100MG	1683	Get Quote
500MG	3375	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

GSK854
Note

Research use only, not for human use.
Brief Description

GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury, and adverse remodeling in the ischemic heart.
Description

GSK854 is a potent Inhibitor of Troponin I-Interacting Kinase (TNNI3K). GSK854 is a suitable lead for identifying new cardiac medicines and have been employed as in vivo tools in investigational studies aimed at defining the role of TNNI3K within heart failure.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis
Research Area

——
Indication

——

Chemical Information

CAS Number

1316059-00-3
Formula Weight

482.96
Molecular Formula

C18H19ClN6O4S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (517.64 mM; Ultrasonic )
SMILES

CCS(=O)(=O)c1ccc(cc1Nc1cc(Nc2ccc(Cl)cn2)ncn1)S(=O)(=O)NC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Philp J, et al. 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors. J Med Chem. 2018;61(7):3076-3088.?

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