Cart
sales@molnova.com
Cipemastat
CAS No. 174265-38-4
Cipemastat( Ro 32-3555 )
Catalog No. M12643 CAS No. 174265-38-4
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCipemastat
-
NoteResearch use only, not for human use.
-
Brief DescriptionCipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor.
-
DescriptionCipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9); inhibits human collagenases 1, 2 and 3 (Ki of 3.0, 4.4 and 3.4 nM), and Ro 323555 is a selective inhibitor of collagenases over the related stromelysin 1, and gelatinases A and B (Ki of 527, 154 and 59 nM); prevents cartilage breakdown both in vitro and in vivo.Rheumatoid Arthritis Phase 3 Discontinued.
-
In Vitro——
-
In Vivo——
-
SynonymsRo 32-3555
-
PathwayMetabolic Enzyme/Protease
-
TargetMMP
-
RecptorMMP
-
Research AreaInflammation/Immunology
-
IndicationRheumatoid Arthritis
Chemical Information
-
CAS Number174265-38-4
-
Formula Weight436.553
-
Molecular FormulaC22H36N4O5
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name1-Piperidinebutanamide, b-(cyclopentylmethyl)-N-hydroxy-g-oxo-a-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lewis EJ, et al. Br J Pharmacol. 1997 Jun;121(3):540-6.
2. Whittaker M, et al. Chem Rev. 1999 Sep 8;99(9):2735-76.
3. Liechti FD, et al. Infect Immun. 2014 Apr;82(4):1710-8.
4. Brewster M, et al. Arthritis Rheum. 1998 Sep;41(9):1639-44.
molnova catalog
related products
-
GI 254023X
GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE).
-
Cordycepin
Cordycepin is a potent inhibitor of IL-1β-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs.
-
ALOIN (b)
ALOIN?Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
