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PWZ-029

CAS No. 164025-33-6

PWZ-029( PWZ029 )

Catalog No. M12484 CAS No. 164025-33-6

PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PWZ-029
  • Note
    Research use only, not for human use.
  • Brief Description
    PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM.
  • Description
    PWZ-029 is a potent, subtype-selective partial inverse agonist of α5 GABAA receptors with Ki of 30 nM, demonstrates memory enhancing effects in vivo; successfully reverses the 0.3 mg/kg scopolamine-induced deficit in recognition memory at 2 mg/kg dose with no effect on anxiety or muscle tone.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PWZ029
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    164025-33-6
  • Formula Weight
    291.735
  • Molecular Formula
    C14H14ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1N(C)CC2=C(COC)N=CN2C3=CC=C(Cl)C=C13
  • Chemical Name
    8-chloro-3-(methoxymethyl)-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Savi? MM, et al. Brain Res. 2008 May 7;1208:150-9. 2. Mili? M, et al. Behav Brain Res. 2013 Mar 15;241:206-13. 3. Soto PL, et al. Neuropsychopharmacology. 2013 Oct;38(11):2315-25. 4. Timi? Stameni? T, et al. J Psychopharmacol. 2015 Sep;29(9):1013-24.
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