MK-6169

Research use only, not for human use.

MK-6169 is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 1-33 nM.

MK-6169 is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 1-33 nM, retains potency against common resistance-associated substitutions in the major genotypes; shows <10X shift on a majority of the genotypes and mutants tested, other than several mutants, such as GT3a Y93H and GT3a L31V, also show good potency on prototypical GT1a NS3 RASs such as GT1a R155K and GT1a V36M+R155K double substitution, as well as prototypical GT1b NS3 RASs such as GT1b A156T and GT1b D168Y; exhibits good pharmacokinetics in both rat and dog.

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MK6169 | MK 6169

Microbiology/Virology

HCV

HCV

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1620479-63-1

1016.203

C54H62FN9O8S

>98% (HPLC)

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O=C(OC)N[C@@H]([C@H]1CC(C)(C)OCC1)C(N2[C@H](C3=NC=C(C4=CC5=C(N([C@H](C6=CC=C(C7CC7)S6)OC8=CC(C9=CN=C([C@H]%10N(C([C@H](C(C)C)NC(OC)=O)=O)CCC%10)N9)=CC(F)=C8%11)C%11=C5)C=C4)N3)CCC2)=O

Methyl ((S)-2-((S)-2-(5-((S)-6-(5-cyclopropylthiophen-2-yl)-1-fluoro-3-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-6H-benzo[5,6][1,3]oxazino[3,4-a]indol-10-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-1-((R)-2,2-dimethyltetrahydro-2H-

(-20℃)

With Ice Pack

≥ 2 years