ACY-957

Research use only, not for human use.

ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM.

ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM); elicits dependent induction of γ-globin mRNA (HBG) and HbF protein in a variety of primary erythroid progenitor cell culture system, increases GATA2 expression, elevates histone acetylation at well-known GATA2 autoregulatory regions.

ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors.

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ACY957

Cell Cycle/DNA Damage

HDAC

HDAC

Other Indications

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1609389-52-7

429.542

C24H23N5OS

>98% (HPLC)

DMSO : 83.33 mg/mL. 194.00 mM

O=C(C1=CC=C2N=C(N3CCNCC3)C=CC2=C1)NC4=CC(C5=CC=CS5)=CC=C4N

N-[2-Amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide

(-20℃)

With Ice Pack

≥ 2 years