Cart
sales@molnova.com
Givinostat
CAS No. 732302-99-7
Givinostat ( ITF2357 )
Catalog No. M15799 CAS No. 732302-99-7
Givinostat hydrochloride monohydrate is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
|
| 5MG | 41 | In Stock |
|
| 10MG | 73 | In Stock |
|
| 25MG | 144 | In Stock |
|
| 50MG | 259 | In Stock |
|
| 100MG | 381 | In Stock |
|
| 200MG | 542 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGivinostat
-
NoteResearch use only, not for human use.
-
Brief DescriptionGivinostat hydrochloride monohydrate is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
-
DescriptionGivinostat hydrochloride monohydrate is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
-
In Vitro——
-
In Vivo——
-
SynonymsITF2357
-
PathwayCell Cycle/DNA Damage
-
TargetHDAC
-
RecptorHD1-A| HD1-B| HD2
-
Research AreaInflammation/Immunology
-
Indication——
Chemical Information
-
CAS Number732302-99-7
-
Formula Weight475.97
-
Molecular FormulaC??H??ClN?O?
-
Purity>98% (HPLC)
-
SolubilityDMSO:95 mg/mL (199.59 mM); Ethanol:3 mg/mL (6.3 mM); Water:<1 mg/mL (<1 mM)
-
SMILESO=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl.O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.
molnova catalog
related products
-
MPI_5a
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM).
-
Givinostat
Givinostat or gavinostat, aslo known as ITF2357, is a potent and orally active histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
-
AES-350
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively).
