Cart
sales@molnova.com
CGP-53353
CAS No. 145915-60-2
CGP-53353( DAPH-7 )
Catalog No. M11980 CAS No. 145915-60-2
CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 136 | In Stock |
|
| 5MG | 123 | In Stock |
|
| 10MG | 188 | In Stock |
|
| 25MG | 432 | In Stock |
|
| 50MG | 732 | In Stock |
|
| 100MG | 1190 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCGP-53353
-
NoteResearch use only, not for human use.
-
Brief DescriptionCGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM.
-
DescriptionCGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM; also inhibits prionogenic Sup35 fibrillization (IC50= 3.4 uM) and inhibits de novo Aβ42 assembly in vitro.
-
In VitroCGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells.CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage. Cell Proliferation AssayCell Line:A10 (cell proliferation induced by glucose) Concentration:1 μM Incubation Time:48-96 hours Result:Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations.
-
In Vivo——
-
SynonymsDAPH-7
-
PathwayAngiogenesis
-
TargetPKC
-
RecptorPKC
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number145915-60-2
-
Formula Weight365.34
-
Molecular FormulaC20H13F2N3O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : ≥ 50 mg/mL (136.86 mM)
-
SMILESO=C1NC(C2=C1C=C(NC3=CC=C(F)C=C3)C(NC4=CC=C(F)C=C4)=C2)=O
-
Chemical Name5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kouroedov A, et al. Circulation. 2004 Jul 6;110(1):91-6.
2. Wang H, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7159-64.
3. Chalfant CE, et al. Mol Endocrinol. 1996 Oct;10(10):1273-81.
molnova catalog
related products
-
Protein Kinase C 19-...
Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.
-
Bryostatin 1
Bryostatin 1 (NSC 339555) is a macrocyclic lactone derived from a marine invertebrate, fuctions as an activator of PKC with high binding affinity (Ki=1.35 nM).
-
Delcasertib
Delcasertib is a potent and selective inhibitor of δ-protein kinase C (δPKC).
