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LXS196

CAS No. 1874276-76-2

LXS196( —— )

Catalog No. M20328 CAS No. 1874276-76-2

LXS196 is a potent selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM 0.4 nM and 3.1 μM for PKCα PKCθ and GSK3β respectively).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	138	In Stock
5MG	131	In Stock
10MG	188	In Stock
25MG	351	In Stock
50MG	492	In Stock
100MG	724	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

LXS196
Note

Research use only, not for human use.
Brief Description

LXS196 is a potent selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM 0.4 nM and 3.1 μM for PKCα PKCθ and GSK3β respectively).
Description

LXS196 is a potent selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM 0.4 nM and 3.1 μM for PKCα PKCθ and GSK3β respectively).
In Vitro

——
In Vivo

Animal Model:Mice implanted with 92.1 GNAQ mutant uveal melanoma cells.Dosage:15, 30, 75, 150 mg/kg Administration:P.O. (bid) for 35 days Result:Dose-dependently suppressed the tumor growth.
Synonyms

——
Pathway

Angiogenesis
Target

PKC
Recptor

PKC
Research Area

Cancer
Indication

Colorectal Cancer; Malignant melanoma; Solid tumours; Uveal melanoma

Chemical Information

CAS Number

1874276-76-2
Formula Weight

472.47
Molecular Formula

C22H23F3N8O?
Purity

>98% (HPLC)
Solubility

DMSO:100 mg/mL (211.65 mM)
SMILES

CC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1C(F)(F)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Protein Kinase C Inhibitor LXS196.

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