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PKCiota-IN-51
CAS No. ——
PKCiota-IN-51( —— )
Catalog No. M16985 CAS No. ——
PKCiota-IN-51 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM。
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePKCiota-IN-51
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NoteResearch use only, not for human use.
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Brief DescriptionPKCiota-IN-51 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM。
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DescriptionPKCiota-IN-51 is a potent and selective inhibitor of Protein Kinase C iota (PKC-ι) with IC50 of 2.7 nM, >15-fold selectivity over PKC-α and PKC-β; inhibits PKC-ι on the phosphorylation of substrate ECT2 in HCCLM3 cells with IC50 of 3.3 uM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPKC
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RecptorPKC
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight427.483
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Molecular FormulaC25H22FN5O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name7-(5-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazolo[1,5-a]pyridin-3-yl)-3-(fluoromethyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kwiatkowski J, et al. J Med Chem. 2018 May 4. doi: 10.1021/acs.jmedchem.8b00060.
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