Candesartan cilexetil( TCV-116 )

Catalog No. M11935 CAS No. 145040-37-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Candesartan cilexetil
Note

Research use only, not for human use.
Brief Description

An angiotensin II receptor antagonist used mainly for the treatment of hypertension.
Description

An angiotensin II receptor antagonist used mainly for the treatment of hypertension.Hypertension Approved.
In Vitro

Cell Viability AssayCell Line:HUVEC cells, HEK293T cells Concentration:0.1 μM, 1 μM, 5 μM, 10 μM Incubation Time:24 h Result:Showed a dose-dependent antiviral effect in ZIKV-infected HUVEC and HEK293T cells.
In Vivo

Animal Model:Dahl salt-sensitive hypertensive ratsDosage:5 mg/kgAdministration:Oral gavage (p.o.)Result:Increased body weight and decreased left ventricular end-diastolic diameter.Decreased the level of iNOS mRNA and ADM mRNA in the left ventricle (LV).Increased the eNOS protein mass in the LV and decreased the immunoreactive ADM contents of LV.Enhanced immunoreactivity for eNOS.Significantly decreased the degree of perivascular fibrosis.Animal Model:Skin wound model rat Dosage:1 mg/kg, 10 mg/kg Administration:Oral Result:Showed 100% re-epithelization of the wound at 1 mg/kg.Significantly suppressed angiogenesis at 10 mg/kg.
Synonyms

TCV-116
Pathway

GPCR/G Protein
Target

Angiotensin Receptor
Recptor

angiotensinIIreceptor
Research Area

Cardiovascular Disease
Indication

Hypertension

CAS Number

145040-37-5
Formula Weight

610.6597
Molecular Formula

C33H34N6O6
Purity

>98% (HPLC)
Solubility

DMSO：≥ 50 mg/mL
SMILES

O=C(OC(C)OC(C1=CC=CC2=C1N(CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3)C(OCC)=N2)=O)OC6CCCCC6
Chemical Name

1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester