AZ82( KIFC1 inhibitor AZ82 )

Catalog No. M11933 CAS No. 1449578-65-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AZ82
Note

Research use only, not for human use.
Brief Description

AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor.
Description

AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM; effectively engages with the minus end-directed KIFC1 motor inside cells to reverse the monopolar spindle phenotype induced by the inhibition of the plus end-directed kinesin Eg5; causes centrosome declustering in BT-549 breast cancer cells with amplified centrosomes.
In Vitro

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In Vivo

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Synonyms

KIFC1 inhibitor AZ82
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Kinesin
Recptor

Kinesin
Research Area

——
Indication

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CAS Number

1449578-65-7
Formula Weight

560.6
Molecular Formula

C28H31F3N4O3S
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL 222.96 mM
SMILES

CCCC1=C(SC(=C1)C(=O)NC(CC2=CN=C(C=C2)C3=CC(=CC=C3)OC(F)(F)F)C(=O)NC4CCNC4)C
Chemical Name

5-methyl-N-((R)-1-oxo-1-(((R)-pyrrolidin-3-yl)amino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide

1. Wu J, et al. ACS Chem Biol. 2013 Oct 18;8(10):2201-8. 2. Yang B, et al. J Med Chem. 2014 Dec 11;57(23):9958-70.

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