Amelparib hydrochloric hydrate( JPI-289 | JPI289 )

Catalog No. M11930 CAS No. 1449233-60-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Amelparib hydrochloric hydrate
Note

Research use only, not for human use.
Brief Description

Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM.
Description

Amelparib hydrochloric hydrate (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM; does not affect cell viability up to 1 mM in rat cortical neuronal cells; attenuates PARP activity restores ATP and NAD+ levels in oxygen glucose deprived (OGD) rat cortical neurons, reduces apoptosis-associated molecules such as apoptosis inducing factor (AIF), cytochrome C and cleaved caspase-3 in the OGD model; JPI-289 is a potential neuroprotective agent which could be useful as a treatment for acute ischaemic stroke.Stroke Phase 2 Clinical.
In Vitro

——
In Vivo

——
Synonyms

JPI-289 | JPI289
Pathway

Cell Cycle/DNA Damage
Target

PARP
Recptor

PARP
Research Area

Neurological Disease
Indication

Stroke

CAS Number

1449233-60-6
Formula Weight

452.373
Molecular Formula

C19H31Cl2N3O5
Purity

>98% (HPLC)
Solubility

——
SMILES

CCOC1=CC(=CC2=C1C3=C(CCCN3)C(=O)N2)CN4CCOCC4.O.O.Cl.Cl
Chemical Name

10-ethoxy-8-(morpholinomethyl)-2,3,4,6-tetrahydrobenzo[h][1,6]naphthyridin-5(1H)-one dihydrochloride dihydrate

1. Kim Y, et al. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):671-679. 2. Kim Y, et al. Mol Neurobiol. 2018 Jan 30. doi: 10.1007/s12035-018-0910-6.

Calculator

molnova catalog