Olmesartan

Research use only, not for human use.

An angiotensin II receptor antagonist which has been used for the treatment of high blood pressure.

An angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. Hypertension Discontinued(In Vitro):Olmesartan (0.7-5 mM; 24, 48 and 72 h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode.(In Vivo):Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species.

Olmesartan (0.7-5 mM; 24, 48 and 72?h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode. Cell Viability Assay Cell Line:Human cervical cancer cell line (HeLa) Concentration:0.7- 5 mM Incubation Time:24, 48 and 72?h Result:IC50s against HeLa cell line are 4.685 and 1.651 mM for 48 and 72 h, respectively.

Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species.

RNH 6270 | CS 088

GPCR/G Protein

Angiotensin Receptor

Angiotensin Receptor

Cardiovascular Disease

Hypertension

144689-24-7

446.5016

C24H26N6O3

>98% (HPLC)

DMSO: ≥ 55 mg/mL

O=C(C1=C(C(C)(O)C)N=C(CCC)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O

1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

(-20℃)

With Ice Pack

≥ 2 years