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D-JNKI-1
CAS No. 1445179-97-4
D-JNKI-1( Brimapitide | AM-111 | XG-102 )
Catalog No. M11885 CAS No. 1445179-97-4
A cell-permeable peptide inhibitor of JNK kinase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 1026 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameD-JNKI-1
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NoteResearch use only, not for human use.
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Brief DescriptionA cell-permeable peptide inhibitor of JNK kinase.
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DescriptionA cell-permeable peptide inhibitor of JNK kinase; blocks apoptotic JNK signaling in brain mitochondria; decreases the expression of CD4(+) and CD8(+) cells, effects T-cell activation, differentiation, and migration in a murine model of chronic colitis; prevents hearing loss from SC transection in the guinea pig model of PA-OM.Other Indication Phase 3 Clinical.
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In VitroD-JNKI-1 (AM-111; 1 μM-1 mM) treatment prevents apoptosis and loss of neomycin-exposed hair cells.
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In VivoD-JNKI-1 (AM-111; 10 μM) prevents nearly all hair cell death and permanent hearing loss induced by neomycin ototoxicity in the scala tympani of the guinea pig cochlea. Local delivery of D-JNKI-1 also prevents acoustic trauma-induced permanent hearing loss in a dose-dependent manner. D-JNKI-1 (0.3 mg/kg, i.p.) reverses these pathological events in the brain mitochondria of the rat and almost completely abolishes cytochrome c release and PARP cleavage. D-JNKI-1 (1 μg/kg, s.c.) results in a significant decrease in the disease activity index, and reduces the expression of CD4+ and CD8+ cells in mice.
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SynonymsBrimapitide | AM-111 | XG-102
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PathwayMAPK/ERK Signaling
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TargetJNK
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RecptorJNK
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1445179-97-4
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Formula Weight3822.44
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Molecular FormulaC164H286N66O40
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Purity>98% (HPLC)
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SolubilityH2O: >50 mg/mL
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SMILESCC(C)CC(C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)N2CCCC2C(=O)NC(CCCNC(=N)N)C(=O)N3CCCC3C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)N)NC(=O)C(CC5=CC=CC=C5)NC(=O)C6CCCN6C(=O)C(CCC(=O)N)NC(=O)C(C(C)C)NC(=O)C7CCCN7C(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)O)N
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Chemical NameNH2-DQSRPVQPFLNLTTPRKPRPPRRRQRRKKRG-COOH
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Eshraghi AA, et al. Otol Neurotol. 2006 Jun;27(4):504-11.
2. Zhao Y, et al. Mol Cell Neurosci. 2012 Mar;49(3):300-10.
3. Kersting S, et al. J Inflamm Res. 2013 May 3;6:71-81.
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