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IQ-1S
CAS No. 23146-22-7
IQ-1S( IQ 1S free acid )
Catalog No. M13653 CAS No. 23146-22-7
A potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87 nM for JNK1, JNK2, and JNK3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 92 | In Stock |
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| 50MG | 160 | In Stock |
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| 100MG | 298 | In Stock |
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| 200MG | 445 | In Stock |
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| 500MG | 718 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIQ-1S
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87 nM for JNK1, JNK2, and JNK3, respectively.
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DescriptionA potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87 nM for JNK1, JNK2, and JNK3, respectively; does not inhibits other kinases that represent potential targets for RA treatment, including GSK-3beta, JAK2, JAK3, PI3Ks, Btk, IKK-2, etc.; inhibits pro-inflammatory cytokine (IL-1α, IL-1β, IL-6, IL-10, TNF-α, IFN-γ, and GM-CSF and nitric oxide production by human and murine monocyte/macrophages; inhibits LPS-induced TNF-α and IL-6 production in MonoMac-6 cells with IC50 of 0.25 and 0.61 uM, respectively; reduces inflammation and cartilage loss associated with CIA in mice model.
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In VitroCompound IQ-1S is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1α, IL-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1S is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μM IQ-1S. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%.
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In VivoWhen mice are dosed with 12.5 and 30 mg/kg IQ-1S (The sodium salt of IQ-1S) i.p., the serum exposure of the compound is also good, with AUC0-12h values of 2.9 and 7.4 μM/h, respectively.
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SynonymsIQ 1S free acid
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PathwayMAPK/ERK Signaling
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TargetJNK
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RecptorJNK1|JNK2|JNK3
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number23146-22-7
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Formula Weight247.2515
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Molecular FormulaC15H9N3O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILESO/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2
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Chemical Name11H-Indeno[1,2-b]quinoxalin-11-one, oxime
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schepetkin IA, et al. Mol Pharmacol. 2012 Jun;81(6):832-45.
2. Schepetkin IA, et al. J Pharmacol Exp Ther. 2015 Jun;353(3):505-16.
3. Atochin DN, et al. Neurosci Lett. 2016 Apr 8;618:45-49.
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