CTx0294885( CTX0294885 | CTX 0294885 | CTX-0294885 )

Catalog No. M11865 CAS No. 1439934-41-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CTx0294885
Note

Research use only, not for human use.
Brief Description

CTX-0294885 is a a novel bisanilino pyrimidine; exhibits inhibitory activity against a broad range of kinases in vitro.
Description

CTX-0294885 is a a novel bisanilino pyrimidine; exhibits inhibitory activity against a broad range of kinases in vitro, and further developed it into a Sepharose-supported kinase capture reagent.(In Vitro):CTX-0294885 is a kinase capture tool in large-scale kinome profiling experiments, with 185 kinases identified as total protein, and 179 identified from TiO2 enrichment for phosphopeptides in MDA-MB-231 cells (by quantitative MS).CTX-0294885 captures all members of the AKT family that is not identified from previous studies using other kinase capture reagents.
In Vitro

CTX-0294885 is a kinase capture tool in large-scale kinome profiling experiments, with 185 kinases identified as total protein, and 179 identified from TiO2 enrichment for phosphopeptides in MDA-MB-231 cells (by quantitative MS).CTX-0294885 captures all members of the AKT family that is not identified from previous studies using other kinase capture reagents.
In Vivo

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Synonyms

CTX0294885 | CTX 0294885 | CTX-0294885
Pathway

Others
Target

Other Targets
Recptor

Kinase capture reagent
Research Area

Other Indications
Indication

——

CAS Number

1439934-41-4
Formula Weight

437.93
Molecular Formula

C22H24ClN7O
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCNCC4)C=C3)=NC=C2Cl
Chemical Name

2-((5-chloro-2-((4-(piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

1. Zhang L, et al. J Proteome Res. 2013 Jul 5;12(7):3104-16.

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