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Engeletin

CAS No. 572-31-6

Engeletin( —— )

Catalog No. M18834 CAS No. 572-31-6

Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 43 In Stock
5MG 39 In Stock
10MG 64 In Stock
25MG 141 In Stock
50MG 221 In Stock
100MG 393 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Engeletin
  • Note
    Research use only, not for human use.
  • Brief Description
    Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml.
  • Description
    Engeletin may serve as a potential anti-inflammatory agent. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant human aldose reductase (IC5 value=1.16 microM).
  • In Vitro
    Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation.
  • In Vivo
    Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Aldose reductase
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    572-31-6
  • Formula Weight
    434.39
  • Molecular Formula
    C21H22O10
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 83.3 mg/mL; 191.76 mM
  • SMILES
    CC1C(C(C(C(O1)OC2C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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