MK-4074( MK 4074 | MK4074 )

Catalog No. M10202 CAS No. 1039758-22-9

COA

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HNMR

HPLC

MSDS

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Product Name

MK-4074
Note

Research use only, not for human use.
Brief Description

MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM.
Description

MK-4074 is a potent, liver-specific, orally active inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 of ~3 nM; lowers lipogenesis, increases ketones and reduces liver triglycerides, increases plasma triglycerides in mice; significantly decreases de novo lipogenesis (DNL) in a dose-dependent manner with ID50 of 0.9 mg/kg in models of obesity, type 2 diabetes and fatty liver.Steatohepatitis Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

MK 4074 | MK4074
Pathway

Metabolic Enzyme/Protease
Target

ACC
Recptor

ACC
Research Area

Other Indications
Indication

Steatohepatitis

CAS Number

1039758-22-9
Formula Weight

565.626
Molecular Formula

C33H31N3O6
Purity

>98% (HPLC)
Solubility

DMSO : 83.3 mg/mL 147.27 mM;
SMILES

CC1=CN(C2=C1C(=CC(=C2)C(=O)N3CCC4(CC3)CC(=O)C5=C(O4)C=CC(=C5)C6=CC(=CN=C6)C(=O)O)OC)C7CC7
Chemical Name

5-(1'-(1-cyclopropyl-4-methoxy-3-methyl-1H-indole-6-carbonyl)-4-oxospiro[chromane-2,4'-piperidin]-6-yl)nicotinic acid

1. Kim CW, et al. Cell Metab. 2017 Aug 1;26(2):394-406.e6.

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