SAR131675

CAS No. 1433953-83-3

SAR131675( —— )

Catalog No. M11844 CAS No. 1433953-83-3

AR131675 is highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 72 In Stock
2MG 39 In Stock
5MG 64 In Stock
10MG 107 In Stock
25MG 226 In Stock
50MG 314 In Stock
100MG 442 In Stock
200MG 607 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SAR131675
  • Note
    Research use only, not for human use.
  • Brief Description
    AR131675 is highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases.
  • Description
    AR131675 is highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. However, it is moderately active on VEGFR-2 with a VEGFR-3/VEGFR-2 ratio of about 10. SAR131675 inhibits VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC50 values of 20 and 45 nM, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    VEGFR
  • Recptor
    VEGFR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1433953-83-3
  • Formula Weight
    358.39
  • Molecular Formula
    C??H??N?O?
  • Purity
    >98% (HPLC)
  • Solubility
    N/A
  • SMILES
    O=C1C(C(NC)=O)=C(N)N(CC)C2=NC(C#C[C@@](COC)(C)O)=CC=C21
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Alam A, et al. SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Mol Cancer Ther. 2012 Aug;11(8):1637-49.
molnova catalog
related products
  • TAK-593

    TAK-593 is an effective VEGFR and PDGFR family inhibitor.

  • VEGFR-2-IN-6

    VEGFR-2-IN-6 (WO 02/059110, example 64) is a potent inhibitor of VEGFR2, a crucial receptor involved in the regulation of angiogenesis .

  • Tyrphostin AG1433

    Tyrphostin AG1433 is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).