Pentamidine isethionate

Research use only, not for human use.

Pentamidine isethionate is an antimicrobial agent for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii.

Pentamidine isethionate is an antimicrobial agent for prevention and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii.(In Vitro):Pentamidine (0-10 μg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner.The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasite Leishmania infantum is determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72 h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin, which is associated with inhibition of DNA synthesis and cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B-->A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein.(In Vivo):Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice.

Cell Viability AssayCell Line:WM9, DU145, C4-2, Hey, WM480, and A549 cells Concentration:0-10 μg/mL Incubation Time:6 days Result:The growth of all six of the cell lines in culture was inhibited in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10 μg/mL.

Animal Model:Athymic nude mice (6 weeks old) injected with WM9 cellsDosage:0.25 mg/mouse Administration:Intramuscular injection; every 2 days; for 4 weeks Result:Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.

Pentamidine Isethionate | Pentamidine isethionate salt | Pentamidine diisethionate

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Other Targets

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Infection

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140-64-7

592.68

C23H36N4O10S2

>98% (HPLC)

DMSO: 100mg/ml(168.73 mM);Water: 100mg/ml(168.73 mM);Ethanol: <1mg/ml

C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O

4,4'-(Pentamethylenedioxy)-dibenzamidine bis(2-hydroxyethanesulfonate)4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid

(-20℃)

With Ice Pack

≥ 2 years