Candesartan( Candesartan, CV11974, CV-1197, CV 11974 )

Catalog No. M11648 CAS No. 139481-59-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Candesartan
Note

Research use only, not for human use.
Brief Description

An angiotensin II receptor antagonist used mainly for the treatment of hypertension.
Description

An angiotensin II receptor antagonist used mainly for the treatment of hypertension.Hypertension Approved(In Vivo):Candesartan (i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi) has neuroprotective effect, reducing neuronal injury, decreasing lesion volume and microglial activation, protecting CBF and improving functional behavior in a mouse model of TBI.
In Vitro

——
In Vivo

Animal Model:C57BL/6 mice (nine-week-old, male, 22–28?g)Dosage:1?mg/kgAdministration:i.p.; 1?mg/kg/day; continuously for 1, 3 or 28 dpi.Result:Reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGF?1 while increasing expression of TGFB3.Showed good motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury.
Synonyms

Candesartan, CV11974, CV-1197, CV 11974
Pathway

GPCR/G Protein
Target

Angiotensin Receptor
Recptor

AT1receptor
Research Area

Cardiovascular Disease
Indication

Hypertension

CAS Number

139481-59-7
Formula Weight

440.45
Molecular Formula

C24H20N6O3
Purity

>98% (HPLC)
Solubility

DMSO: 4.5 mg/mL (100 mM); Ethanol: 0.4 mg/mL (10 mM), with gentle warming （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(C1=C2N(CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)C(OCC)=NC2=CC=C1)O
Chemical Name

2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-7-benzimidazolecarboxylic acid