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CL 316243 disodium
CAS No. 138908-40-4
CL 316243 disodium( CL316243 disodium )
Catalog No. M11615 CAS No. 138908-40-4
CL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 107 | In Stock |
|
| 10MG | 163 | In Stock |
|
| 25MG | 330 | In Stock |
|
| 50MG | 516 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCL 316243 disodium
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NoteResearch use only, not for human use.
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Brief DescriptionCL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM.
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DescriptionCL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM; Displays >10000-fold selective over β1 and β2 receptors; Significantly increases brown adipose tissue thermogenesis and resting metabolic rate in mice, also increases the concentration of insulin receptors and decreases the levels of serum insulin and blood glucose during the glucose overloading test.Obesity Discontinued.
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In Vitro——
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In VivoAnimal Model:Male C57BL/6J mice fed with high-fat diets (HFD; 45%-kcal fat) or a control diet (ND; 10%-kcal fat) for 14 weeks Dosage:0.1 mg/kg/day Administration:once a day; 1 weeks Result:Exhibited a premium effect of obesity in mice.
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SynonymsCL316243 disodium
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PathwayGPCR/G Protein
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research AreaMetabolic Disease
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IndicationObesity
Chemical Information
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CAS Number138908-40-4
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Formula Weight465.8
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Molecular FormulaC20H18ClNNa2O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 20 mg/mL (42.94 mM助)
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SMILESCC(CC1=CC2=C(C=C1)OC(O2)(C(=O)[O-])C(=O)[O-])NCC(C3=CC(=CC=C3)Cl)O.[Na+].[Na+]
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Chemical Name5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Berlan M, et al. J Pharmacol Exp Ther. 1994 Mar;268(3):1444-51.
2. Himms-Hagen J, et al. Am J Physiol. 1994 Apr;266(4 Pt 2):R1371-82.
3. Yoshida T, et al. Life Sci. 1994;54(7):491-8.
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