Fexofenadine

Research use only, not for human use.

Fexofenadine, an antihistamine pharmaceutical drug, is used to treat allergy symptoms, such as nasal congestion, hay fever, and urticaria.

Fexofenadine, an antihistamine pharmaceutical drug, is used to treat allergy symptoms, such as nasal congestion, hay fever, and urticaria. Compared to first-generation antihistamines, Fexofenadine is less able to pass the blood-brain barrier and cause sedation.

Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.Western Blot Analysis Cell Line:Nasal fibroblasts Concentration:100 μM Incubation Time:1 hour Result:Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.

Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis. Animal Model:C57BL/6 mice infected with Trichinella spiralis Dosage:5, 10 and 20 mg/kg Administration:Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks Result:Inhibited eosinophilia in a dose-dependent manner.Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.

Carboxyterfenadine | Allegra | MDL 16.455 | Telfast | Carboxyterfenadine

GPCR/G Protein

Histamine Receptor

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83799-24-0

501.667

C32H39NO4

>98% (HPLC)

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CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years