Vafidemstat( ORY 2001 | ORY-2001 | ORY2001 | Vafidemstat )

Catalog No. M11465 CAS No. 1357362-02-7

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HNMR

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Product Name

Vafidemstat
Note

Research use only, not for human use.
Brief Description

Vafidemstat is a novel potent, selective lysine-specific histone demethylase (LSD1) inhibitor.
Description

Vafidemstat is a novel potent, selective lysine-specific histone demethylase (LSD1) inhibitor.
In Vitro

Vafidemstat (ORY-2001), a dual LSD1/MAO-B inhibitor, is a novel epigenetic agent for the treatment of neurodegenerative diseases. LSD1 is a protein that participates in transcription regulation complexes; its modulation can be used to tweak transcriptional imbalances in neurodegenerative disease and redress neuroinflammation and cognitive deficit. Vafidemstat (ORY-2001) can be used in the treatment of Alzheimer's disease.
In Vivo

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Synonyms

ORY 2001 | ORY-2001 | ORY2001 | Vafidemstat
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

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Indication

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CAS Number

1357362-02-7
Formula Weight

336.395
Molecular Formula

C19H20N4O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (148.64 mM)
SMILES

[H][C@@]1([C@@](NCC2=NN=C(N)O2)([H])C1)C(C=C3)=CC=C3OCC4=CC=CC=C4
Chemical Name

1,3,4-Oxadiazole-2-methanamine, 5-amino-N-[(1R,2S)-2-[4-(phenylmethoxy)phenyl]cyclopropyl]-