SAH-EZH2

Research use only, not for human use.

EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.

EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.

The selectivity of SAH-EZH2 activity is highlighted by the lack of a SAH-EZH2 effect on the H3K4, H3K9 and H3K36 methyl marks. MLL-AF9 leukemia cells, which are dependent on PRC2, undergo growth arrest and monocyte-macrophage differentiation upon treatment with SAH-EZH2, consistent with observed changes in expression of PRC2-regulated, lineage-specific marker genes.

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Chromatin/Epigenetic

Histone Demethylase

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1453222-26-8

3432.05

C155H256N48O40

>98% (HPLC)

water:1 mg/mL

[H][C@]([C@H](O)C)(C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)C(C)C)=O)=O)CCC(N)=O)=O)[H])=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCCN)=O)CC2=CNC3=CC=CC=C23)=O)CCC(O)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(C)C)=O)[H])=O)CCC(N)=O)=O)NC([C@@H](NC([C@@]4(CCC/C=C/CCC[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC5=CC=CC=C5)=O)CO)=O)CO)=O)CC(N)=O)=O)CCCNC(N)=N)=O)(C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N4)=O)CC(C)C)=O)[H])=O)CCCCN)=O)C)C)=O)CCCNC(N)=N)=O

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(-20℃)

With Ice Pack

≥ 2 years